Just an update for anyone that might be interested...
Have been talking with a friend with directly applicable, first hand experience. He ordered his 2006 CC with Goodyear G670RV 295/80R22.5 tires. However, it came through with Toyo 12R 22.5's. CC was transitoning that year from the TOYO's to the G670RV's. CC, being the good company that it was, let him take delivery of the coach with the TOYO's and promised to replace the tires - which they soon did. He tells me that the G670RV's fit with no problems and the the ride was much improved (went from good to great). The TOYO's had a harsher ride than the goodyears - as you might expect a truck tire might provide vs the G670 - RV specific tire.
I was also contacted by "Tim" at Goodyear. His position was that the "dual clearence" would not be a problem and that the G670RV's would be a much better choice.
My plan is to go with the G670RV's