Size of tire will also dictate availability. That’s why I dropped the 295/80 R22.5 (coach only size) and went with a 12R22.5. Plus it gave me a little bit of overdrive. the 295/75R22.5 is often considered a “suitable” replacement, it’s also readily available. it cannot handle the load and is dangerous on our coach and most coaches when installed by someone not understanding why the 295/80 was the tire selected by the chassis manufacturer.